Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Satish, S.
- Antihyperlipidemic Activity in Aqueous Leaf Extract of Ciceracida in Wistar Albino Rats
Abstract Views :167 |
PDF Views:0
Authors
Mohibul Hoque
1,
S. Satish
2
Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 142-146Abstract
Hyperlipidemia is a major cause of Atherosclerosis and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of aqueous leaf extract of ciceracida (ALEC) against hyperlipidemia induced by high fat diet (HFD) in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each. Group I received normal diet. Group II received high fat diet. Group III received a high fat diet supplemented with simvastatin 4mg/kg. Group IV received high fat diet supplemented with aqueous leaves extract of ciceracida 100 mg/kg. Group V received a high fat diet supplemented with aqueous leaves extract of ciceracida 250 mg/kg and Group VI received a high fat diet supplemented with aqueous leaves extract of ciceracida 500mg/kg for 30 days. At the end of the experiments on the 30th, day blood samples was collected 4 h after the last dose of administration using light ether anesthesia. Blood samples were collected separately from retro orbital sinus puncture into sterilized dry centrifugation tubes. Blood serum was analysed for its hypolipidemic activity. Serum analysis showed decrease cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, atherogenic index, body weight, food intake and an increase cholesterol excretion and serum high density lipoprotein content was observed in the group III, IV, V and VI rats as compared to the group II rats, and there is no histopatholological alteration in rat aorta was seen. Thus it could be concluded that ALEC is potent antihyperlipidemic activity.Keywords
Ciceracida Leaf, Lipoprotein, Hyperlipidemic Diet, Obesity.References
- Robert W, Mahley, Thomas P, Bersot Goodman and Gilman‟s. The Pharmacological Basis Of Therapeutics, McGraw-Hill medical publication 2006; 11: 977-978.
- Stone NJ, Robinson J, Lichtenstein AH, Merz NB, Blum CB. Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults, A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, American heart association 2013; 3024-3025.
- Kasper D L, Braunwald E, Fauci A S, Hauser, Longo, Jameson. Harrison‟s principles of internal medicine, Mc Graw Hill 2008; 16: 2288.
- Rang HP, Dale MM, Ritter JM, Flower RJ. Rang And Dale‟s. Pharmacology, 6th Edn, London Elsevier 2008: 189-196.
- Nicki RC, Brian RW, Stuart HR. Davidson‟s Principle and Practice Of Medicine 2010; 21: 577-579.
- Nadkarni KM, Nadkarni AK. Indian Materia Medica., Popular Prakasham: Mumbai; 1 (3): 1976-1019.
- Prodyut mondal, niroj bhuyan, sonjit das, mritunjay kumar, sudarshana borah, kabita mahato International journal of pharmacy and biological sciences 2013; 3(1): 575-589.
- Ashish mahajan,praful patel, antihyperlipidemic and antiatherosclerosclerotic activity of rimonabant in wistar albino rats. Research journal of pharmaceutical, biological and chemical sciences 2013; 49(4): 340-349.
- Pankit P. Anti hyperlipidemic activity of tephrosia purpurea plants extracts in poloxomer 407 induced hyperlipidemic rats, international journal of pharmacological research 2014; 4(4) : 186-193.
- Trease GE, Evans MC. Text book of pharmacognosy, London, Bailiare Tindall 2003;12:193-336.
- Hassarajani S, Souza TD, Mengi SA and Chattopadhayay. Indian J Pharmacol 2007; 39:196-200.
- Friedewald WT, Levy RI and Frederickson DS. Clin Chem 1972; 18:499-502.
- Muruganandan S, Srinivasan K, Gupta S, Gupta PK and Lal J. J Ethnopharmacology 2005; 97: 497–501.
- Chumark P, Khunawat P, Sanvarinda Y, S Phornchirasilp et al. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. Leaves. Elsevier 2008; 116: 439-446.
- Yokozawa T, Ishida A, Cho EJ, Nakagawa T. Phytomed 2003; 10:17–22.
- Vijaimohan K, Jainu M, Sabitha KE, Subramaniyam S, Anandhan C, Shyamala CS. Life Sci 2006; 79: 448–454.
- Zulet MA, Barber A, Garcin H, Higueret P, Martınez JA. J American Coll Nutr 1999; 18: 36–42.
- Antidiabetic Activity in Aqueous Leaf Extract of Ciceracida Linn in Alloxan Induced Diabetes Rats Model
Abstract Views :178 |
PDF Views:0
Authors
Mohibul Hoque
1,
S. Satish
2
Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 152-156Abstract
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4th, 7th and 10th day similarly in sub acute study animals were tested for blood glucose level on 14th, 21th and 30th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.Keywords
Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.References
- Ijaolat.O, Osunkiyesi A, Taiwoa. A, Osenio. A, Lanreiyanday, Ajayij, O, Andoyede R.T. Antidiabetic effect of ipomoea batatas in normal and alloxan-induced diabetic rats, Journal of Applied Chemistry 2014; 7(5): 16-25.
- Shoback G and Gardener D. prevalence of diabetes 2011; 15: 499-501.
- Mellisa C and William D. Diabetes mellitus 2010; 13-16.
- Joshi sr, Parikhrm. India - diabetes capital of the world: now heading towards hypertension, J Assoc Physicians India 2007; 55: 323–334.
- Whiting Dr, Guariguata, Weil C, Shaw. Diabetes atlas global estimates of the prevalence of diabetes for 2011 and 2030, Diabetes res Clinpract 2011; 94: 311–321.
- Beretta A. Campanha De Prevencao E Diagnostico Do Diabetes Realizada Pela Uniararas E Prefeitura Municipal Na Cidade De Araras. Laes and Haes 2001; 22(131): 188-200.
- Singh R, Sidhups, Vadhera S, Ssitaljs, Bhatia S. Extra-cellular invertase of Rhizobium japonicum and its role in free sugar metabolism in the developing ischolar_main nodules of sesbania grandiflora, Physiologiaplantarum, 1980;48(4): 504–508.
- Prodyut Mondal, Niroj Bhuyan, Sonjit Das, Mritunjay Kumar, Sudarshana Borah, Kabita Mahato International Journal of Pharmacy and Biological Sciences 2013; 3(1): 575-589.
- Trease GE, Evans MC. Text book of Pharmacognosy, London, Bailiare Tindall 2003;12:193-336.
- Patil AG, Kolisp, Patil Da, Narayane VS, Phatakav. Preliminary studies on antihyperglycemic effect of aqueous slurry of averrhoa carambola l Fruits in streptozotocin induced diabetic rats, International Journal for Pharmaceutical Research Scholars 2014; 4(1): 684- 695.
- Vivekkumar S, Sureshkumar, Hitesh JP, Shivakumar H. Hypoglycemic activity of ficusglomarata in alloxan induced diabetic rats, International Journal of Pharmaceutical Sciences Review and Research 2010; 1(2): 18-22.
- T. Sindhu S. Rajamanikandan, P. Ragavendran, D. Sophia, P. Meenakshi, d. Durgapriya and V. K. Gopalakrishnan. Antidiabetic activity of mollugonudicaulis against alloxan induced diabetic rats, International Journal of Applied Biology and Pharmaceutical Technology, 3 nov-dec 2010; 511-519.
- Venkatesh, S, Reddy, G. D., Reddy, B. M, Ramesh, M, and Rao, A, V, N. Antihyperglycemic activity of Caralluma attenuata. Fitoterapia 2003; 74(3): 274-279.
- Cazarolli, L. H, Zanatta, L, Alberton, E. H, Reis Bonorino Figueiredo, M. S., Folador, P., Damazio, R. G, and Mena Barreto Silva, F. R. Flavonoids: cellular and molecular mechanism of action in glucose homeostasis. Mini Reviews in Medicinal Chemistry 2008; 8(10): 1032-1038.
- Ahmed, S. M, Swamy BM, V., Gopkumar, P., Dhanapal, R., and Chandrashekara, V. M. Anti-diabetic activity of Terminalia catappa Linn. leaf extracts in alloxaninduced Diabetic Rats 2005; 4(1): 38-39.
- Jelodar, G, Mohsen, M, and Shahram, S. Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. African Journal of Traditional, Complementary and Alternative Medicines 2008; 4(3): 299-305.
- Bnouham, M., Ziyyat, A, Mekhfi, H, Tahri, A, and Legssyer, A. Medicinal plants with potential antidiabetic activity-A review of ten years of herbal medicine research (1990-2000). International Journal of Diabetes and Metabolism 2006; 14(1): 1-25.
- Atangwho, I. J, Ebong, P. E, Egbung, G. E, Akpaso, M. I, and Asuquo, E. E. Histological Effect of Combined Extracts of Veronica Amygdalina and Azadirachta indica on Normal and Diabetic Rats: the Pancreas and Liver. Research Journal of Agriculture and Biological Sciences 2010; 6(4): 514-521.